Ulcer & Glaucoma 2
|Forty-one patients with glaucoma and 30 age-matched controls underwent
upper gastrointestinal endoscopies, gastric mucosal biopsies and rapid urease
test (CLOtest). Saliva samples were also tested. Serum anti-H pylori-specific
IgG was analysed. Helicobacter pylori-positive patients received a triple
eradication treatment (omeprazole, clarithromycin and amoxicillin). All patients
were observed for 2 years with the same antiglaucoma
therapy. Helicobacter pylori
was detected in 88% of glaucoma cases and in 47% of controls
(p<.001). Helicobacter pylori eradication was successful in 83%
of treated patients. Glaucoma parameters were improved in the subgroup of
patients where H. pylori eradication was successful (intraocular pressure
p<.001 ; visual field parameters p±.01).
On behalf of professor Kountouras, I would like to thank you for quoting our research concerning the link between H pylori infection and glaucoma, published last year in Ophthalmology. Furthermore, I would like to inform you that the second part of our research has just been published in the Archives of Internal Medicine. We shall be glad if you also inform the readers of your site of our ongoing research in the field.
Christos Zavos, MD
You will find, in Ophthalmology, the original work of the month. It comes us from Thessalonique. This not randomised exploratory study compared 41 glaucomatous patients (of which nine had pseudoexfoliation) to a control group paired by age. Histological results of the biopsies made by endoscopy objectified an incidence of Helicobacter Pylori infection very significantly higher among glaucomatous patients. The most reasonable assumption is a predisposing common factor to both affections. However a possible pathogen role of Helicobacter Pylori in the glaucomatous disease, argued by the authors, is certainly not to draw aside and constitutes a base of future investigations.
Kountouras J, et al. Relationship between Helicobacter Pylori Infection and Glaucoma. Ophthalmology 2001;108:599-604
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